Coming from Colorado, I-70 enters flat plains in Kansas. This portion of I-70 was the first segment to start being paved and to be completed in the interstate system. It is given the nickname "Main Street of Kansas" as the interstate extends from the Western border to the Eastern border covering 424 miles and passing through most of the state's principal cities in the process.
I-70 crossing on the Lewis & Clark Viaduct over the Kansas River from Kansas to Missouri in Kansas City.In Salina, I-70 intersects with I-135, the longest "spur" route in the Interstate system, forming the latter's northern terminus.
In Topeka, I-70 intersects a child route, I-470, twice. At the eastern intersection, the Kansas Turnpike merges, making I-70 into a toll road. This is one of only two sections of I-70 that are tolled. (The other is in Pennsylvania where it is part of the Pennsylvania Turnpike and is concurrent with I-76.) I-70 carries this designation from Topeka to Bonner Springs, the eastern terminus of the turnpike. There is also a third child route in Topeka, I-335, which runs from I-470 south to meet up with I-35 in the Flint Hills town of Emporia. Just past the Bonner Springs Toll Plaza I-70 crosses I-435 for the first time. This intersection allows those traveling to points not generally east of Kansas City to avoid the downtown traffic by using I-435, which encircles the Kansas City metropolitan area. Further down the highway in Kansas City, Kansas, approximately 3 miles before the 18th Street Expressway, I-70 is intersected again by another child route. This route, I-635, runs from I-35 at its southern terminus up to I-29, just about 5 miles across the Missouri river, at its northern terminus. From I-635 to just past the 7th Street (US 169) exit, I-70 runs adjacent to the second largest rail yard in the United States (only the Chicago rail yard is larger). Here I-670 (also designated "Alternate 70" on some signs) diverges, providing a more direct route that rejoins I-70 proper a few miles east in Missouri. The highway passes over the former stockyards and rail yard when it crosses the Kansas River on the Lewis & Clark Viaduct into downtown Kansas City, Missouri.